PAPER Morales R, Moreno-Gonzalez I, Soto C

Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases.

PLoS Pathog. 2013 Sep;9(9):e1003537. PubMed: 24068917

PAPER Jiao B, Guo JF, Wang YQ, Yan XX, Zhou L, Liu XY, Zhang FF, Zhou YF, Xia K, Tang BS, Shen L

C9orf72 mutation is rare in Alzheimer's disease, Parkinson's disease, and essential tremor in China.

Front Cell Neurosci. 2013;7:164. PubMed: 24068985

PAPER Rubio-Moscardo F, Setó-Salvia N, Pera M, Bosch-Morató M, Plata C, Belbin O, Gené G, Dols-Icardo O, Ingelsson M, Helisalmi S, Soininen H, Hiltunen M, Giedraitis V, Lannfelt L, Frank A, Bullido MJ, Combarros O, Sánchez-Juan P, Boada M, Tárraga L, Pastor P, Pérez-Tur J, Baquero M, Molinuevo JL, Sánchez-Valle R, Fuentes-Prior P, Fortea J, Blesa R, Muñoz FJ, Lleó A, Valverde MA, Clarimón J

Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer's Disease Patients Alter Calcium Homeostasis.

PLoS One. 2013;8(9):e74203. PubMed: 24069280

PAPER Crouzin N, Baranger K, Cavalier M, Marchalant Y, Cohen-Solal C, Roman FS, Khrestchatisky M, Rivera S, Féron F, Vignes M

Area-Specific Alterations of Synaptic Plasticity in the 5XFAD Mouse Model of Alzheimer's Disease: Dissociation between Somatosensory Cortex and Hippocampus.

PLoS One. 2013;8(9):e74667. PubMed: 24069328

PAPER Brownlow ML, Benner L, D'Agostino D, Gordon MN, Morgan D

Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology.

PLoS One. 2013;8(9):e75713. PubMed: 24069439

PAPER Carnero-Pardo C, Cruz-Orduña I, Espejo-Martínez B, Martos-Aparicio C, López-Alcalde S, Olazarán J

Utility of the mini-cog for detection of cognitive impairment in primary care: data from two spanish studies.

Int J Alzheimers Dis. 2013;2013:285462. PubMed: 24069544

Paul Saftig on LOADed ADAM 10 Mutations Bolster Amyloid Hypothesis

COMMENT The human ADAM10 mutations Q170H and R181G within the prodomain of the protein have been previously found in several late-onset AD families (Kim et al., 2009). To validate the pathogenicity of the mutations, classical transgenic mice expressing wild type

PAPER Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M

Requirement of Notch activation during regeneration of the intestinal epithelia.

Am J Physiol Gastrointest Liver Physiol. 2009 Jan;296(1):G23-35. Epub 2008 Nov 20 PubMed: 19023031

PAPER Yi P, Hadden C, Kulanthaivel P, Calvert N, Annes W, Brown T, Barbuch RJ, Chaudhary A, Ayan-Oshodi MA, Ring BJ

Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans.

Drug Metab Dispos. 2010 Apr;38(4):554-65. Epub 2010 Jan 14 PubMed: 20075192

PAPER Hopkins CR

ACS chemical neuroscience molecule spotlight on semagacestat (LY450139).

ACS Chem Neurosci. 2010 Aug 18;1(8):533-4. PubMed: 22778845

Carlos Cruchaga on RNA Sequencing Helps Identify Functional Variants from GWAS

COMMENT These papers have numerous implications. Together with the paper published by ENCODE (ENCODE Project Consortium, 2012), this work clearly highlights the importance of the non-coding DNA on gene regulation and expression. One repercussion of these findings

PAPER Kumar A, Gibbs JR, Beilina A, Dillman A, Kumaran R, Trabzuni D, Ryten M, Walker R, Smith C, Traynor BJ, Hardy J, Singleton AB, Cookson MR

Age-associated changes in gene expression in human brain and isolated neurons.

Neurobiol Aging. 2013 Apr;34(4):1199-209. PubMed: 23177596

PAPER Hernandez DG, Nalls MA, Moore M, Chong S, Dillman A, Trabzuni D, Gibbs JR, Ryten M, Arepalli S, Weale ME, Zonderman AB, Troncoso J, O'Brien R, Walker R, Smith C, Bandinelli S, Traynor BJ, Hardy J, Singleton AB, Cookson MR

Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.

Neurobiol Dis. 2012 Jul;47(1):20-8. PubMed: 22433082

PAPER Montgomery SB, Lappalainen T, Gutierrez-Arcelus M, Dermitzakis ET

Rare and common regulatory variation in population-scale sequenced human genomes.

PLoS Genet. 2011 Jul;7(7):e1002144. PubMed: 21811411

In the Works

Other This database is a work in progress and will be expanded over time. In addition to regular updates to the existing biomarkers, we plan to add additional biomarkers over time. We have begun by curating CSF biomarkers but plan to systematically incorporate